Case of the Week: Max

Max is a sixteen-year-old Siamese mix. His owner brought him into the clinic because he had stopped eating and drinking and was drooling constantly. On examining him, I found that he was thin, very dehydrated and had a fever. I also saw a large ulcer on his tongue. My first thought was that it was likely he had severe chronic kidney disease and a poor prognosis. We drew blood and urine samples from him and did a panel to evaluate his organ and immune system functions.

His blood test results were surprisingly good. His kidney values were increased, but only a little above normal and he was concentrating his urine fairly well. These results indicated that his kidneys were still functioning well but that Max was dehydrated. I also found that his protein levels and one of his white blood cell counts were increased, which indicated an infection in his body.

It was at this point that Max's history became as important in diagnosing his problem as his blood tests and physical exam. Max's owner had recently adopted a new cat into their home. Max had not had any vaccines since he was a kitten. Therefore, he was not protected against the common viruses that are very contagious and widespread among cats, especially those in shelters. It is very difficult to test for the Herpes or Calici viruses that cause upper respiratory disease in cats. However, Max's symptoms - lethargy, not eating, running a fever, and an ulcer on his tongue - were consistent with upper respiratory disease.

Max received intravenous fluids at the clinic for two days and recovered slowly. We gave him subcutaneous fluids (under his skin) for a few more days and he gradually began eating and grooming again.

Vaccinations are important in all cats to help prevent disease. Because of widespread vaccination, we rarely see Panleukopenia (Distemper) or Rabies in cats in this country. The Herpes and Calici viruses that cause upper respiratory disease are very contagious and stable viruses that still cause problems in many cats. However, severe disease from these viruses are usually only seen in young cats and cats that have not been well vaccinated. Cats that are current on their vaccines have good immunity to these viruses and show minimal signs of illness when exposed.

It's important that owners not become complacent about their cats protection. Even indoor cats can be exposed to viruses. Always discuss with your veterinarian what vaccines are best for your cat.

For more information and guidelines for vaccinations throughout your cat's life, see our Life Stages Health Care Recommendations on our website.

Dr. Judy Karnia

Case of the Week: Bianca

Bianca is a seven and a half year old medium haired cat. Her owners brought her to the clinic because she was having trouble eating and her bottom jaw was shaking. She would also hold her mouth open as if she was having difficulty closing it.

On her exam, she was very sensitive to touch around her mouth and pulled her head away when I tried to open it. I could see tartar build-up on her teeth and gingivitis. There was gum recession at her upper right canine tooth and swelling of the gum there. We ran a blood panel and it was normal except for a mild increase in the protein levels due to inflammation or infection. Bianca also tested negative for Feline Leukemia Virus and Feline Immunodeficiency Virus.

Bianca's problems could have been due to a neurologic disease or a problem with her jaw. However, I thought the most likely cause of Bianca's problems was pain in her teeth and started her on antibiotics and pain medication. She started feeling better and was eating normally again with a couple of days. We anesthetized her to clean her teeth and exam them more thoroughly. Her upper canine tooth had a large resportive lesion and moved in the socket. The dental radiographs showed the root of the tooth was still present. By careful probing of the teeth, I also found resorptive lesions in three other teeth and a large periodontal pocket around the other upper canine tooth. Almost all of her incisors and one of the lower canine teeth were already missing.

I extracted both upper canine teeth and the three teeth with resorptive lesions. I sutured the gums closed with absorbable stitches and did a thorough cleaning of the teeth, polished them and applied a sealant. I gave her an anti-inflammatory medication to control the inflammation and discomfort and sent her home with more antibiotics and pain medications.

While Bianca was under anesthesia we found another hidden problem. Jill, our veterinary assistant, found a tapeworm segment near Bianca's anus. Bianca is an indoor cat and therefore likely to have had the tapeworm for years. Even indoor cats can carry intestinal parasites and often show no symptoms. Fecal tests can help us find many intestinal parasites but tapeworms usually do not shed eggs that would be found in those tests. The tapeworm didn't appear to be causing any problems at the time for Bianca, and it was just a lucky find while she was here. I gave her an injection to clear the tapeworms from her body.

At Bianca's progress exam a week later, she was doing very well. Her owners said that she was more active and playing, and eating well. She was not showing any more signs of pain.

Dental disease is very common in cats and can cause varying levels of pain depending on the severity of the disease. Many cats can suffer a good deal of pain but do not show any signs. Bianca likely had discomfort long before she showed signs. This is why it is important for cats to have regular semi-annual exams and dental cleanings when recommended by your veterinarian. Cat's won't tell us what's wrong and they often hide symptoms. Your veterinarian and technicians can spot trouble before it becomes severe.

Dr. Judy Karnia

October 2010 Happenings via #constantcontact

October 2010 Happenings via #constantcontact

Case of the Week- Tommy

Tommy is another of our senior patients. He is a fifteen and a half year old long-haired indoor cat. A year and a half ago at his exam, I saw that he had dental disease and multiple teeth with lesions called Feline Odontoclastic Resorptive Lesions (FORL) so we scheduled him for a dental cleaning under anesthesia. His blood and urine tests were completely normal.

At his dental cleaning, his dental radiographs revealed that the body was resorbing many of the roots of the teeth. This is a common problem in cats, and while we do not know what causes this resorption, we do see it frequently when there are FORLs. I extracted four of Tommy's teeth and sutured the gums closed.

Because his owners had noticed that Tommy seemed to have some discomfort in his hind end, we then took radiographs of Tommy's hips and lower spine. The radiographs are the best way to evaluate a cat for arthritis. I noted some mild changes in the bones around his hips. The cartilage is not visible on the radiographs but even mild changes in the bones indicate that there are changes to the health of the joint.

Tommy did very well after his dental procedure and started eating well immediately. I prescribed a glucosamine/chondroitin product for him to help his joints but he would not eat it in his food. Three months later, he started vomiting and his owners brought him back into the clinic. He was constipated and had a thickened section of intestinal tract. His anal sacs were full so I expressed them out and started him on lactulose, a stool softener. He did well on this and I could no longer feel the thickened intestine at his progress exam a week later. I also started him on Fortiflora, a probiotic, at this time to keep his intestinal tract healthy.

A month later, Tommy was back in the clinic. He seemed very uncomfortable in his hind end and would not jump. He reacted strongly to my manipulation of his hips so it appeared his arthritis was worsening. I prescribed a non-steroidal anti-inflammatory medication and a gel with glucosamine. He immediately improved with the medication and was moving around much better.

Two months later, Tommy was lethargic and gagging. I examined him and saw his throat was inflamed and his lymph nodes were enlarged. His blood panel revealed an elevated white blood cell count indicating infection or inflammation. I prescribed antibiotics and pain medications. Tommy's owners had stopped his anti-inflammatory medication because they were concerned with possible side effects. If a non-steroidal anti-inflammatory medication is given at too high doses, it can cause stomach ulcers and kidney damage. However, Tommy was not moving well since they had stopped it. I explained how the medication has a low risk of side effects if it is used at the proper dosage and that it was important to keep Tommy comfortable.

For the following year, I only saw Tommy once for his vaccines and blood panel recheck. This summer however, he developed a skin condition, which we had a little difficulty treating fully. It did not appear to be due to any skin parasites or fungal, did not clear up with antibiotics, and did not seem to be a reaction to any of his medications. I recommended his owners try him on a hypoallergenic diet made by Royal Canin. Cats typically develop allergies to food or environmental causes earlier in their lives. We rarely see such sensitivity arise this late in a cat's life. But, with no other logical causes, it seemed our best shot was a long shot.

Last week, Tommy came into the clinic for his six-month exam and to recheck his blood and urine tests. His skin and fur looked great. Our hunch about food allergies turned out to be correct. The new diet is doing the trick.

Tommy is also coping very well with his arthritis. He has been on the anti-inflammatory medication for a year now with no side effects or changes to his blood or urine values. He is moving well and all bodily functions appear to be doing very well. We did decide to start an injectable medication called Adequan, which helps the joint fluid and cartilage. It may enable us to lower his anti-inflammatory medication some and keep his joints feeling better a little longer.

Tommy is another good example for how senior cats can develop multiple problems. Because his owners are very diligent in having his problems addressed and consistent with his medications and diet, Tommy is enjoying his later years. His arthritis will never go away, but we can minimize his discomfort and keep him as active as possible.

Senior Feline Care - Arthritis

One of the more common ailments to afflict senior cats is arthritis. Clinical studies have shown that 22-64% of all cats and 90% of cats older than twelve years old have radiographic (x-ray) signs of arthritis. Cats most commonly develop arthritis in their hips, elbows, knees, ankles, and spine.

Arthritis causes pain and loss of movement of the joints. The word arthritis literally means joint inflammation (arth=joint, ritis=inflammation). Inflammation is a reaction of the body that causes swelling, redness, pain, and loss of motion in an affected area. Normally, inflammation is the way the body responds to an injury or to the presence of disease agents, such as viruses or bacteria. During this reaction, many cells of the body's defense system - called the immune system - rush to the injured area to wipe out the cause of the problem, clean up damaged cells, and repair tissues that have been hurt. Once the battle is won, the inflammation normally goes away and the area becomes healthy again.

In many forms of arthritis, the inflammation does not go away as it should. Instead, it becomes part of the problem, damaging healthy tissues of the body. This may result in more inflammation and more damage - a continuing cycle. The damage that occurs can change the bones and other tissues of the joints, sometimes affecting their shape and making movement hard and painful.

As with most illnesses and injuries in cats, the symptoms of arthritis can bey very subtle and easily missed especially if they are gradual in onset. Many of them are dismissed as simply being signs of "old age" and not necessarily indicative of an actual, treatable (or at least manageable) ailment. Symptoms can include:
unusual sleep patterns;
eliminating outside the litter box;
hiding;
avoiding interaction with people or other pets in the home;
dislike of being stroked or brushed;
decreased grooming, reluctance or inability to jump as high as they once could or to go up stairs;
reluctance to jump down or landing ungracefully/with difficulty;
decrease or change in play;
stiff gait or lameness.

Diagnosing arthritis involves a thorough exam that may reveal pain, crepitus, and/or swelling in the joints. Pain can be difficult to interpret in cats during an exam because they are not in their familiar environment. To help with this, we rely on your observations of the cat's behavior at home as well as diagnostic tools as radiographs (x-rays). Radiographs can show changes in the bony structures of the joints, which do indicate developing arthritis. However, there can be cartilage changes that cannot be seen on radiographs.

Although treatment may not turn your senior cat into an agile and active kitten, it will relieve pain and distress and enable your cat to do normal activities. Treating arthritis is tackled with a three-pronged approach: nutrition, medication and environmental changes.

Nutrition: Just as with humans, being overweight can exacerbate symptoms and pain associated with arthritis. If your cat is on the heavier side, we will work with you to help her lose some of those extra ounces. We can calculate calories needed and monitor weight loss with regular progress exams. Additionally, there are prescription diet formulas specifically designed to help with mobility issues in older cats. Finally, we may recommend fatty acid supplements that many help reduce inflammation.

Medications: Most medications used for arthritis in cats are not approved for use in cats by the FDA and are "off-label". This is due to the cost of the research to prove the safety and efficacy in cats. The medications, however, have been used extensively in cats by veterinarians and can be used safely if used at proper doses and with proper monitoring, including regular medical progress exams, blood panels, and communication with your veterinarian.

There are a variety of medication types available to help your cat:
Glucosamine/condroitin promotes the health of the cartilage and joint fluid. Adquean, delivered by subcutaneous injection, is a polysulfate gylcosaminoglycan which also helps cartilage and joint fluid. Stronger medications include NSAIDS (Non-steroidal Anti-inflammatory Drugs), which control inflammation in the joints providing pain relief. NSAIDS can cause gastrointestinal upset and damage to the kidneys, although the side effects are rare with low doses. Analgesics or steroids might also be part of your cat's arthritis therapy depending on various factors.

Many cats with arthritis benefit from multiple medications and supplements. By using various types of medications, we can keep the doses of each lower to minimize side effects. All medication treatments require regular monitoring by your veterinarian through progress exams.

Environmental modifications: In order to improve your arthritic cat's quality of life around the home, here a few suggestions for easy modifications to accommodate her. There are many litter boxes out on the market now that have lower sides, or a least a low entry side, making it easier for her to get into the box and reducing the risks of eliminating outside of it. You can also mound the litter to one side to help her position herself more comfortably when defecating. You might also consider adding additional litter boxes around the house, especially if you live in a multi-story house, so she doesn't have to walk as far to reach one.

Because access to heights is important to most cats, consider adding ramps or steps to help her get to her favorite places. There are many manufacturers of such products, specifically for older cats, or you can do a simple rearrangement of the furniture for her. Make sure she has easy access to food and water. If you feed her on a counter, add steps for her, or start feeding her on a lower plane, or on the floor.

Arthritis is a lifelong disease, and one that is likely to progress over time. The sooner it can be diagnosed and treatment begun, the more comfortable your cat will be.

Case of the Week - Midnight

Midnight is an eight and a half year old domestic short hair cat. She first came into the clinic nine months ago because she was straining to urinate and defecate. I examined her and found that she was constipated and obese. We want cats to be a healthy 5/9 on our body condition score scale. Midnight was an 8/9. Her bladder was too small to obtain a urine sample, but I suspected a urinary tract infection due to her symptoms. We gave her an enema and started antibiotics and medication to soften her stool. We also advised her owner to start feeding canned food and started her on a prescription diet food to start weight loss and relieve her constipation.

Two weeks later at her progress exam, Midnight had improved and was urinating and defecating better. However, a urinalysis showed that there was still blood in her urine so we ran more tests. Her bladder and kidneys appeared normal on an ultrasound and a urine culture ruled out bacterial infection. Since no underlying cause could be found, I diagnosed her with "cystitis" which is inflammation of the bladder. In many cases, we do not know the cause of the cystitis but it can be caused and/or made worse by stress. Stress in a cat's life can be very subtle and can be related to their environment, other animals, their diet, or painful medical conditions.

I prescribed Metacam for Midnight to help ease the inflammation and discomfort in her bladder. Metacam is a non-steroidal anti-inflammatory medication. As with any medication, repeated and long-term use may cause some side effects. If we make sure we use proper dosages and the cat is monitored well, Metacam relieves discomfort in many cats with cystitis and arthritis.

Midnight immediately started feeling much better. She was much more active. Her owner said that she had noticed stiffness in Midnight's hind end previously, but she was now moving much better.

At her progress exam a month later, Midnight was still doing very well. She was urinating and defecating normally. She no longer needed stool softeners. Her diet was doing well and she had lost almost a pound by this point. However, her urinalysis showed that she still had blood in her urine indicating that her cystitis was not fully resolved.

In order to try to improve this, we started Adequan injections to help the bladder and the likely arthritis. Adequan is polysulfated glycosaminoglycans; these are normal components of joints and the bladder wall. We give it as an injection under the skin - weekly or bi-weekly - then fewer injections as the cat improves.

Midnight is currently given Adequan injections once monthly and Metacam every fourth day and continues to do well. She has lost almost two pounds and is active and feeling well. We needed to switch her prescription food to a low calorie food with high protein rather than high fiber. This has produced more regular bowel movements for her but still helped with her continued weight loss.

Nearing nine years old, Midnight is now classified as a senior cat. Like human senior citizens, it is common to see multiple problems in senior cats. Keeping a healthy weight and feeding quality cat food helps all aspects of their health. But even trim senior cats can be plagued with troublesome and intersecting problems. Many times we have to prescribe multiple medications to address the various problems and make sure we are treating them as well as possible.

Dr. Judy Karnia

Senior Feline Health Care - Diagnostic Testing

As we mentioned in our senior wellness blog, many of the diseases and conditions that commonly develop in senior cats are more easily managed when they are caught in their early stages. This helps maintain or even improve your older cat's quality of life.

In this blog, we will explain in a little more detail what exactly the tests we run tell us about your cat's health.

Many of the same technologies and medical diagnostic testing that help humans live longer, healthier lives are also available to your cat. Even a few standard tests allow us to gather a wealth of information about the well-being and health of your cat. These tests become increasingly important as your cat continues to age.

The most common lab test we run in our clinic is a combination blood panel consisting of a complete blood count and blood chemistry. A Complete Blood Count (CBC) is a series of tests that evaluate the number of cells in circulation in the blood. White blood cells, WBC, help fight infection and inflammation and can increase with cancer. Red blood cells, RBC, carry oxygen to the tissues. Platelets allow clotting of the blood and are another indication of the health of the bone marrow. Overall, the CBC tests for anemia, infection, inflammation and the health of blood cells and the bone marrow.

A blood chemistry panel is performed to get an initial overview of the health and function of body organs. This panel surveys many of the organ systems of the body to make sure they are working properly. Our chemistry test checks the following organ functions: liver, kidney, pancreas, muscle, bone, thyroid and electrolytes.

For many conditions, such as chronic renal disease and diabetes mellitus, a urinalysis should also be run to provide a complete picture of organ function. For example, in verifying renal disease, the specific gravity - or concentration - of urine is a key diagnostic tool in addition to the blood chemistry numbers. In diagnosing diabetes, glucose levels in the urine are examined.

Finally, we recommend radiographs (x-rays), first to establish a baseline at a younger age, and then regularly to monitor any changes or developments. Cats do develop arthritis, but as with many illnesses, they hide their discomfort and it's not always readily apparent until the condition becomes severe. There may be subtle signs, such as taking extra steps to get places, jumping from floor to stool to bed instead of straight from floor to bed, or refraining from jumping at all. Arthritis pain can be managed with a variety of different treatments, including a specialized diet.

Ultimately, the tests performed are designed to ensure the best quality and longevity of life possible for your cat.